Bioactive Small Molecules
Enzo Life Sciences dBET6 (10mg). CAS: 1950634-92-0
dBET6 is chemical degrader of BET bromodomain proteins based on PROTAC and led a collapse of global elongation that phenocopies CDK9 inhibition. Purity: ≥99%. Solubility: Soluble in DMSO (240 mg/mL). Insoluble in water. Long Term Storage: -20°C.
Cayman Chemical 4-methyl-a-EthyltryptamIn 5mg
A homolog of α-ethyltryptamine; intended for forensic and research applications
Sigma Aldrich Fine Chemicals Biosciences DREADD Agonist 21 dihydroc25MG
DREADD Agonist 21 dihydroc25MG
Abcam GSK-3787, PPARdelta antagonist, 5MG
MW 392.8 Da, Purity >98%. Potent, selective, irreversible peroxisome proliferator-activated receptor delta (PPARδ) antagonist (IC₅₀ = 130 nM). No affinity for PPARα or PPARγ. Orally active. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide | 2098346-67-7 | MFCD32198081 | 98.9% | 340.41 | C17H16N4O2S | 25 MG
DCAF15 ligand-1 is a small-molecule research ligand for the E3 ligase DCAF15. It is commonly used as a building block in degrader and PROTAC synthesis and for studies of ubiquitin-proteasome pathway modulation. Analytical documentation (certificate of analysis) accompanies supplied material and provides recommended storage and handling instructions.
- Ligand for DCAF15 E3 ligase used in degrader synthesis and research.
- High purity as reported in certificate of analysis (98.87%).
- Molecular formula C17H16N4O2S and molecular weight 340.41 g/mol.
- CAS registry number 2098346-67-7 for unambiguous identification.
- Supplied as a small solid quantity suitable for synthesis (example package: 25 mg).
- Stability and storage recommendations provided in the certificate of analysis.
Creative Biomart Nivolumab
Nivolumab is a PD-1 blocking antibody used to treat melanoma non small-cell lung cancer renal cell cancer head and neck cancer and Hodgkin lymphoma.
Cayman Chemical ConglobatIn C1 5mg
A bacterial metabolite; cytotoxic to NS-1 mouse myeloma cells (IC50 = 1.05 UG/ml)
Cayman Chemical ANTIBODY L-778 123 5mg
A dual inhibitor of FTase and GGTase I (IC50s = 2 and 98 nM, respectively); inhibits prenylation of FTase and GGTase I substrates HDJ2 and Rap1a in PSN-1 pancreatic tumor cells (EC50s = 92 and 6,760 nM, respectively); inhibits prenylation of the oncogenic protein Ki-Ras in PSN-1 cells in a concentration-dependent manner; reduces HDJ2 and Rap1a prenylation ex vivo in dog PBMCs when administered at a dose of 35-50 mg/kg per day; has no effect on Ki-Ras prenylation in patient-derived PBMCs; inhibits lectin-induced expression of the T cell activation markers CD71 and CD25 on human PMBCs (IC50s = 6.48 and 84.1 μM, respectively); inhibits IL-2-induced proliferation of CTLL2 cells (IC50 = 0.81 μM)
Cayman Chemical ANTIBODY IM-93 10mg
A dual inhibitor of ferroptosis and NETosis; inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC50s =1.8 and 1.9 nM, respectively), as well as decreases PMA-induced NETosis and lipid peroxidation in isolated human peripheral blood neutrophils at 1.6-25 µM; inhibits hydrogen peroxide-induced necrosis in HL-60 cells (IC50 = 0.45 µM), but has no effect on necroptosis induced by Fas ligand in combination with Z-VAD-FMK and cycloheximide in Jurkat cells or pyroptosis induced by S. aureus and P. aeruginosa in THP-1 cells at 25 µM
Apexbio Technology LLC Darifenacin HBr, 10mg. Cas: 133099-07-7 MFCD: MFCD08141803. Selective M3 muscarinic receptor antagonist
DarifenacinHBr(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9 [1]. Themuscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or themuscarinic 3, is amuscarinic acetylcholine receptorencoded by the human geneCHRM3. Other sizes are available. Please inqury us for quote.
Cayman Chemical SordarInsodIum salt 5mg
An inhibitor of fungal protein synthesis; binds to EF-2 in the presence of ribosomes; inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM); inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml); inhibits the growth of C. albicans (MIC = 8 μg/ml) but not C. glabrata or C. neoformans (MICs = >125 μg/ml)
Cayman Chemical ANTIBODY T-863 1mg
A DGAT-1 inhibitor (IC50 = 15 nM); selective for DGAT-1 over DGAT-2 and ACAT-1 (IC50s = >10 and 12 μM, respectively); inhibits triacylglycerol synthesis in HuTu 80 cells (IC50 = 4 nM); reduces plasma triacylglycerol levels, the ratio of triacylglycerols:diacylglycerols, and body weight in a mouse model of diet-induced obesity at 20 mg/kg
Cell Signaling Technology PathScanR RP Total B-Raf Sandwich ELISA Kit 20 Kit
PathScanR RP Total B-Raf Sandwich ELISA Kit 20 Kit
Cayman Chemical ANTIBODY SPHINX31 1mg
A potent inhibitor of SRPK1 (IC50 = 5.9 nM); inhibits phosphorylation of SRSF1, an SRPK1 substrate, in PC3 cells (EC50 = 360 nM); increases expression of the anti-angiogenic VEGF-A165b splice variant in RPE cells; inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization (2 μg per eye)
Apexbio Technology LLC Biotin-HPDP, 10mg. Cas: 129179-83-5 MFCD: MFCD00078541. Sulfhydryl-reactive biotinylation reagent, pyridyldithiol-activated
Biotin-HPDP (N-[6-(biotinamido)hexyl]-3-(2-pyridyldithio)propionamide), a sulfhydryl-reactive biotinylation agent, is a water-insoluble reagent that requires the dissolution of suitable solvents, including dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). Other sizes are available. Please inqury us for quote.